Title |
STRAD pseudokinases regulate axogenesis and LKB1 stability
|
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Published in |
Neural Development, March 2014
|
DOI | 10.1186/1749-8104-9-5 |
Pubmed ID | |
Authors |
Biliana O Veleva-Rotse, James L Smart, Annette F Baas, Benjamin Edmonds, Zi-ming Zhao, Allyson Brown, Lillian R Klug, Kelly Hansen, Gabrielle Reilly, Alexandria P Gardner, Krishnaveni Subbiah, Eric A Gaucher, Hans Clevers, Anthony P Barnes |
Abstract |
Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation. It is allosterically regulated by two related and evolutionarily conserved pseudokinases, STe20-Related ADapters (STRADs) α and β. The roles of STRADα and STRADβ in the developing nervous system are not fully defined, nor is it known whether they serve distinct functions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 5 | 14% |
Researcher | 4 | 11% |
Other | 3 | 8% |
Student > Doctoral Student | 3 | 8% |
Other | 9 | 25% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 31% |
Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Neuroscience | 5 | 14% |
Unspecified | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 8 | 22% |