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Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

Overview of attention for article published in Journal of Neuroinflammation, March 2014
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Title
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy
Published in
Journal of Neuroinflammation, March 2014
DOI 10.1186/1742-2094-11-41
Pubmed ID
Authors

Wei Xie, Lun Cai, Yunhong Yu, Liang Gao, Limin Xiao, Qianchao He, Zhijun Ren, Yuanzheng Liu

Abstract

Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Brazil 1 1%
Unknown 93 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 17%
Student > Bachelor 15 16%
Student > Ph. D. Student 13 14%
Student > Doctoral Student 6 6%
Other 6 6%
Other 17 18%
Unknown 22 23%
Readers by discipline Count As %
Neuroscience 16 17%
Agricultural and Biological Sciences 16 17%
Medicine and Dentistry 12 13%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 7 7%
Unknown 32 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2020.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Journal of Neuroinflammation
#2,244
of 2,951 outputs
Outputs of similar age
#165,816
of 236,019 outputs
Outputs of similar age from Journal of Neuroinflammation
#40
of 61 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,019 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.