Title |
Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses
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Published in |
Molecular Brain, March 2014
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DOI | 10.1186/1756-6606-7-16 |
Pubmed ID | |
Authors |
Carlos Sindreu, Àlex Bayés, Xavier Altafaj, Jeús Pérez-Clausell |
Abstract |
Zinc concentrates at excitatory synapses, both at the postsynaptic density and in a subset of glutamatergic boutons. Zinc can modulate synaptic plasticity, memory formation and nociception by regulating transmitter receptors and signal transduction pathways. Also, intracellular zinc accumulation is a hallmark of degenerating neurons in several neurological disorders. To date, no single zinc extrusion mechanism has been directly localized to synapses. Based on the presence of a canonical PDZ I motif in the Zinc Transporter-1 protein (ZnT1), we hypothesized that ZnT1 may be targeted to synaptic compartments for local control of cytosolic zinc. Using our previously developed protocol for the co-localization of reactive zinc and synaptic proteins, we further asked if ZnT1 expression correlates with presynaptic zinc content in individual synapses. |
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