Title |
Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition
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Published in |
Acta Neuropathologica Communications, March 2014
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DOI | 10.1186/2051-5960-2-26 |
Pubmed ID | |
Authors |
Jon B Toledo, Michael W Weiner, David A Wolk, Xiao Da, Kewei Chen, Steven E Arnold, William Jagust, Clifford Jack, Eric M Reiman, Christos Davatzikos, Leslie M Shaw, John Q Trojanowski, for the Alzheimer’s Disease Neuroimaging Initiative |
Abstract |
Based on previous studies, a preclinical classification for Alzheimer's disease (AD) has been proposed. However, 1) specificity of the different neuronal injury (NI) biomarkers has not been studied, 2) subjects with subtle cognitive impairment but normal NI biomarkers (SCINIB) have not been included in the analyses and 3) progression to mild cognitive impairment (MCI) or dementia of the AD type (DAT), referred to here as MCI/DAT, varies between studies. Therefore, we analyzed data from 486 cognitively normal (CN) and 327 DAT subjects in the AD Neuroimaging Initiative (ADNI)-1/GO/2 cohorts. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | <1% |
United States | 1 | <1% |
Unknown | 105 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 25 | 23% |
Student > Ph. D. Student | 23 | 21% |
Other | 10 | 9% |
Student > Master | 8 | 7% |
Student > Doctoral Student | 6 | 6% |
Other | 15 | 14% |
Unknown | 20 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 23 | 21% |
Neuroscience | 21 | 20% |
Psychology | 18 | 17% |
Agricultural and Biological Sciences | 8 | 7% |
Computer Science | 3 | 3% |
Other | 10 | 9% |
Unknown | 24 | 22% |