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Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR

Overview of attention for article published in Genome Medicine, March 2014
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62 Mendeley
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Title
Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR
Published in
Genome Medicine, March 2014
DOI 10.1186/gm537
Pubmed ID
Authors

Chrissy h Roberts, Wei Jiang, Jyothi Jayaraman, John Trowsdale, Martin J Holland, James A Traherne

Abstract

The Killer-cell Immunoglobulin-like Receptor (KIR) gene complex has considerable biomedical importance. Patterns of polymorphism in the KIR region include variability in the gene content of haplotypes and diverse structural arrangements. Droplet digital PCR (ddPCR) was used to identify different haplotype motifs and to enumerate KIR copy number variants (CNVs). ddPCR detected a variety of KIR haplotype configurations in DNA from well-characterised cell lines. Mendelian segregation of ddPCR estimated KIR2DL5 CNVs was observed in Gambian families and CNV typing of other KIRs was shown to be accurate when compared to an established quantitative PCR method.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 24%
Student > Ph. D. Student 9 15%
Other 7 11%
Student > Bachelor 5 8%
Student > Postgraduate 5 8%
Other 12 19%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 47%
Biochemistry, Genetics and Molecular Biology 7 11%
Medicine and Dentistry 6 10%
Immunology and Microbiology 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 6%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2014.
All research outputs
#16,047,334
of 25,373,627 outputs
Outputs from Genome Medicine
#1,401
of 1,585 outputs
Outputs of similar age
#129,026
of 235,877 outputs
Outputs of similar age from Genome Medicine
#21
of 23 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,585 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,877 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.