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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice
|
|---|---|
| Published in |
Skeletal Muscle, July 2017
|
| DOI | 10.1186/s13395-017-0132-z |
| Pubmed ID | |
| Authors |
Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson |
| Abstract |
Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the important role of satellite cells during muscle development, we hypothesized that the necessity of satellite cells for adaptation to an imposed hypertrophic stimulus depends on maturational age. Pax7(CreER)-R26R(DTA) mice were treated for 5 days with vehicle (satellite cell-replete, SC+) or tamoxifen (satellite cell-depleted, SC-) at 2 months (young) and 4 months (mature) of age. Following a 2-week washout, mice were subjected to sham surgery or 10 day synergist ablation overload of the plantaris (n = 6-9 per group). The surgical approach minimized regeneration, de novo fiber formation, and fiber splitting while promoting muscle fiber growth. Satellite cell density (Pax7+ cells/fiber), embryonic myosin heavy chain expression (eMyHC), and muscle fiber cross sectional area (CSA) were evaluated via immunohistochemistry. Myonuclei (myonuclei/100 mm) were counted on isolated single muscle fibers. Tamoxifen treatment depleted satellite cells by ≥90% and prevented myonuclear accretion with overload in young and mature mice (p < 0.05). Satellite cells did not recover in SC- mice after overload. Average muscle fiber CSA increased ~20% in young SC+ (p = 0.07), mature SC+ (p < 0.05), and mature SC- mice (p < 0.05). In contrast, muscle fiber hypertrophy was prevented in young SC- mice. Muscle fiber number increased only in mature mice after overload (p < 0.05), and eMyHC expression was variable, specifically in mature SC+ mice. Reliance on satellite cells for overload-induced hypertrophy is dependent on maturational age, and global responses to overload differ in young versus mature mice. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 35% |
| United Kingdom | 3 | 8% |
| Canada | 2 | 5% |
| Australia | 1 | 3% |
| Belgium | 1 | 3% |
| Norway | 1 | 3% |
| Colombia | 1 | 3% |
| Spain | 1 | 3% |
| Brazil | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 11 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 57% |
| Scientists | 15 | 41% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 109 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 22% |
| Student > Master | 22 | 20% |
| Researcher | 13 | 12% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 7 | 6% |
| Other | 14 | 13% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 34% |
| Sports and Recreations | 15 | 14% |
| Medicine and Dentistry | 11 | 10% |
| Agricultural and Biological Sciences | 9 | 8% |
| Nursing and Health Professions | 4 | 4% |
| Other | 9 | 8% |
| Unknown | 24 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2021.
All research outputs
#1,436,635
of 23,599,036 outputs
Outputs from Skeletal Muscle
#21
of 369 outputs
Outputs of similar age
#29,661
of 313,375 outputs
Outputs of similar age from Skeletal Muscle
#1
of 6 outputs
Altmetric has tracked 23,599,036 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 369 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,375 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them