Title |
Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR)
|
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Published in |
BMC Cancer, March 2014
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DOI | 10.1186/1471-2407-14-170 |
Pubmed ID | |
Authors |
Jisun Kim, Woosung Lim, Eun-Kyu Kim, Min-Kyoon Kim, Nam-Sun Paik, Sang-Seol Jeong, Jung-han Yoon, Chan Heun Park, Sei Hyun Ahn, Lee Su Kim, Sehwan Han, Seok Jin Nam, Han-Sung Kang, Seung Il Kim, Young Bum Yoo, Joon Jeong, Tae Hyun Kim, Taewoo Kang, Sung-Won Kim, Yongsik Jung, Jeong Eon Lee, Ku Sang Kim, Jong-Han Yu, Byung Joo Chae, So-Youn Jung, Eunyoung Kang, Su Yun Choi, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han |
Abstract |
Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have shown that the antidiabetic drug metformin has anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed to evaluate the direct anti-tumor effect of metformin in non-diabetic postmenopausal women with estrogen-receptor (ER) positive breast cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 86 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 13% |
Student > Bachelor | 11 | 13% |
Other | 10 | 11% |
Researcher | 9 | 10% |
Student > Ph. D. Student | 8 | 9% |
Other | 18 | 20% |
Unknown | 21 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 45% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 5 | 6% |
Nursing and Health Professions | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 4 | 5% |
Unknown | 27 | 31% |