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Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR)

Overview of attention for article published in BMC Cancer, March 2014
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Title
Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR)
Published in
BMC Cancer, March 2014
DOI 10.1186/1471-2407-14-170
Pubmed ID
Authors

Jisun Kim, Woosung Lim, Eun-Kyu Kim, Min-Kyoon Kim, Nam-Sun Paik, Sang-Seol Jeong, Jung-han Yoon, Chan Heun Park, Sei Hyun Ahn, Lee Su Kim, Sehwan Han, Seok Jin Nam, Han-Sung Kang, Seung Il Kim, Young Bum Yoo, Joon Jeong, Tae Hyun Kim, Taewoo Kang, Sung-Won Kim, Yongsik Jung, Jeong Eon Lee, Ku Sang Kim, Jong-Han Yu, Byung Joo Chae, So-Youn Jung, Eunyoung Kang, Su Yun Choi, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han

Abstract

Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have shown that the antidiabetic drug metformin has anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed to evaluate the direct anti-tumor effect of metformin in non-diabetic postmenopausal women with estrogen-receptor (ER) positive breast cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
United States 1 1%
Unknown 86 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 13%
Student > Bachelor 11 13%
Other 10 11%
Researcher 9 10%
Student > Ph. D. Student 8 9%
Other 18 20%
Unknown 21 24%
Readers by discipline Count As %
Medicine and Dentistry 40 45%
Biochemistry, Genetics and Molecular Biology 5 6%
Agricultural and Biological Sciences 5 6%
Nursing and Health Professions 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 4 5%
Unknown 27 31%