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The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection

Overview of attention for article published in Retrovirology, March 2014
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Citations

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18 Mendeley
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Title
The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection
Published in
Retrovirology, March 2014
DOI 10.1186/1742-4690-11-22
Pubmed ID
Authors

Lily Tsai, Ivan Tasovski, Ana Rachel Leda, Mario PS Chin, Cecilia Cheng-Mayer

Abstract

Severe genetic bottleneck occurs during HIV-1 sexual transmission whereby most infections are initiated by a single transmitted/founder (T/F) virus. Similar observations had been made in nonhuman primates exposed mucosally to SIV/SHIV. We previously reported variable clinical outcome in rhesus macaques inoculated intravaginally (ivg) with a high dose of R5 SHIVSF162P3N. Given the potential contributions of viral diversity to HIV-1 persistence and AIDS pathogenesis and recombination between retroviral genomes increases the genetic diversity, we tested the hypothesis that transmission of multiple variants contributes to heightened levels of virus replication and faster disease progression in the SHIVSF162P3N ivg-infected monkeys.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 44%
Student > Master 2 11%
Professor 1 6%
Student > Bachelor 1 6%
Professor > Associate Professor 1 6%
Other 0 0%
Unknown 5 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Biochemistry, Genetics and Molecular Biology 3 17%
Medicine and Dentistry 2 11%
Immunology and Microbiology 2 11%
Mathematics 1 6%
Other 0 0%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2014.
All research outputs
#13,404,726
of 22,747,498 outputs
Outputs from Retrovirology
#622
of 1,105 outputs
Outputs of similar age
#109,442
of 220,818 outputs
Outputs of similar age from Retrovirology
#9
of 23 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,818 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.