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A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma

Overview of attention for article published in Journal of Translational Medicine, March 2014
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  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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3 X users

Citations

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31 Dimensions

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49 Mendeley
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Title
A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma
Published in
Journal of Translational Medicine, March 2014
DOI 10.1186/1479-5876-12-65
Pubmed ID
Authors

Prasong Khaenam, Darawan Rinchai, Matthew C Altman, Laurent Chiche, Surachat Buddhisa, Chidchamai Kewcharoenwong, Duangchan Suwannasaen, Michael Mason, Elizabeth Whalen, Scott Presnell, Wattanachai Susaengrat, Kimberly O’Brien, Quynh-Ahn Nguyen, Vivian Gersuk, Peter S Linsley, Ganjana Lertmemongkolchai, Damien Chaussabel

Abstract

There are diverse molecules present in blood plasma that regulate immune functions and also present a potential source of disease biomarkers and therapeutic targets. Genome-wide profiling has become a powerful method for assessing immune responses on a systems scale, but technologies that can measure the plasma proteome still face considerable challenges. An alternative approach to direct proteome assessment is to measure transcriptome responses in reporter cells exposed in vitro to plasma. In this report we describe such a "transcriptomic reporter assay" to assess plasma from patients with sepsis, which is a common and severe systemic infectious process for which physicians lack efficient diagnostic or prognostic markers.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Sweden 1 2%
Unknown 46 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 27%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 4 8%
Student > Bachelor 3 6%
Other 3 6%
Other 11 22%
Unknown 10 20%
Readers by discipline Count As %
Medicine and Dentistry 14 29%
Agricultural and Biological Sciences 11 22%
Biochemistry, Genetics and Molecular Biology 6 12%
Immunology and Microbiology 5 10%
Unspecified 1 2%
Other 2 4%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2014.
All research outputs
#14,191,572
of 22,747,498 outputs
Outputs from Journal of Translational Medicine
#1,777
of 3,977 outputs
Outputs of similar age
#117,692
of 220,818 outputs
Outputs of similar age from Journal of Translational Medicine
#20
of 55 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,818 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.