Title |
Voltage-Gated Sodium Channel Expression in Mouse DRG after SNI Leads to Re-Evaluation of Projections of Injured Fibers
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Published in |
Molecular Pain, January 2014
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DOI | 10.1186/1744-8069-10-19 |
Pubmed ID | |
Authors |
Cédric J Laedermann, Marie Pertin, Marc R Suter, Isabelle Decosterd |
Abstract |
Dysregulation of voltage-gated sodium channels (Na(v)s) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain. A complete transcriptional characterization of the different isoforms of Na(v)s under normal and pathological conditions had never been performed on mice, despite their widespread use in pain research. Na(v)s mRNA levels in mouse dorsal root ganglia (DRG) were studied in the spared nerve injury (SNI) and spinal nerve ligation (SNL) models of neuropathic pain. In the SNI model, injured and non-injured neurons were intermingled in lumbar DRG, which were pooled to increase the tissue available for experiments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 2% |
Switzerland | 1 | <1% |
United Kingdom | 1 | <1% |
France | 1 | <1% |
Romania | 1 | <1% |
United States | 1 | <1% |
Unknown | 116 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 19% |
Researcher | 22 | 18% |
Student > Master | 20 | 16% |
Student > Doctoral Student | 10 | 8% |
Student > Bachelor | 10 | 8% |
Other | 23 | 19% |
Unknown | 15 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 36 | 29% |
Agricultural and Biological Sciences | 27 | 22% |
Medicine and Dentistry | 16 | 13% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 7 | 6% |
Unknown | 20 | 16% |