Title |
Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells
|
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Published in |
BMC Complementary Medicine and Therapies, March 2014
|
DOI | 10.1186/1472-6882-14-97 |
Pubmed ID | |
Authors |
Liza J Burton, Petrina Barnett, Basil Smith, Rebecca S Arnold, Tamaro Hudson, Kousik Kundu, Niren Murthy, Valerie A Odero-Marah |
Abstract |
Snail transcription factor can induce epithelial-mesenchymal transition (EMT), associated with decreased cell adhesion-associated molecules like E-cadherin, increased mesenchymal markers like vimentin, leading to increased motility, invasion and metastasis. Muscadine grape skin extract (MSKE) has been shown to inhibit prostate cancer cell growth and induce apoptosis without affecting normal prostate epithelial cells. We investigated novel molecular mechanisms by which Snail promotes EMT in prostate cancer cells via Reactive Oxygen Species (ROS) and whether it can be antagonized by MSKE. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 67% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
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United States | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 21% |
Student > Bachelor | 3 | 16% |
Student > Doctoral Student | 2 | 11% |
Student > Master | 2 | 11% |
Professor | 1 | 5% |
Other | 3 | 16% |
Unknown | 4 | 21% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Chemistry | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Computer Science | 1 | 5% |
Other | 2 | 11% |
Unknown | 7 | 37% |