Title |
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder
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Published in |
Genome Biology, March 2014
|
DOI | 10.1186/gb-2014-15-3-r25 |
Pubmed ID | |
Authors |
Ruqi Tang, Hyun Ji Noh, Dongqing Wang, Snaevar Sigurdsson, Ross Swofford, Michele Perloski, Margaret Duxbury, Edward E Patterson, Julie Albright, Marta Castelhano, Adam Auton, Adam R Boyko, Guoping Feng, Kerstin Lindblad-Toh, Elinor K Karlsson |
Abstract |
Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% of the human population. While highly heritable, complex genetics has hampered attempts to elucidate OCD etiology. Dogs suffer from naturally occurring compulsive disorders that closely model human OCD, manifested as an excessive repetition of normal canine behaviors that only partially responds to drug therapy. The limited diversity within dog breeds makes identifying underlying genetic factors easier. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 26% |
United Kingdom | 9 | 21% |
France | 2 | 5% |
Grenada | 1 | 2% |
Portugal | 1 | 2% |
Sweden | 1 | 2% |
Spain | 1 | 2% |
Nigeria | 1 | 2% |
Russia | 1 | 2% |
Other | 2 | 5% |
Unknown | 12 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 64% |
Scientists | 12 | 29% |
Science communicators (journalists, bloggers, editors) | 2 | 5% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
France | 1 | <1% |
Taiwan | 1 | <1% |
Austria | 1 | <1% |
Unknown | 169 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 18% |
Researcher | 29 | 17% |
Student > Bachelor | 21 | 12% |
Student > Master | 18 | 10% |
Other | 15 | 9% |
Other | 31 | 18% |
Unknown | 28 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 28% |
Biochemistry, Genetics and Molecular Biology | 24 | 14% |
Veterinary Science and Veterinary Medicine | 22 | 13% |
Medicine and Dentistry | 16 | 9% |
Neuroscience | 10 | 6% |
Other | 21 | 12% |
Unknown | 33 | 19% |