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Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs

Overview of attention for article published in Genome Biology, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
17 X users
googleplus
2 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
108 Dimensions

Readers on

mendeley
218 Mendeley
citeulike
3 CiteULike
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Title
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
Published in
Genome Biology, March 2014
DOI 10.1186/gb-2014-15-3-r51
Pubmed ID
Authors

Hilary C Martin, Shivangi Wani, Anita L Steptoe, Keerthana Krishnan, Katia Nones, Ehsan Nourbakhsh, Alexander Vlassov, Sean M Grimmond, Nicole Cloonan

Abstract

MicroRNAs (miRNAs) bind to mRNAs and target them for translational inhibition or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the seed region at the 5' end of the miRNA. The importance of seed sites is supported by experimental evidence, although there is growing interest in interactions mediated by the central region of the miRNA, termed centered sites. To investigate the prevalence of these interactions, we apply a biotin pull-down method to determine the direct targets of ten human miRNAs, including four isomiRs that share centered sites, but not seeds, with their canonical partner miRNAs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 <1%
United States 2 <1%
Spain 2 <1%
Australia 1 <1%
Brazil 1 <1%
Italy 1 <1%
Mexico 1 <1%
Germany 1 <1%
Malaysia 1 <1%
Other 1 <1%
Unknown 205 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 29%
Researcher 36 17%
Student > Master 26 12%
Student > Bachelor 21 10%
Student > Doctoral Student 17 8%
Other 35 16%
Unknown 20 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 91 42%
Biochemistry, Genetics and Molecular Biology 50 23%
Medicine and Dentistry 16 7%
Computer Science 13 6%
Immunology and Microbiology 5 2%
Other 15 7%
Unknown 28 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2015.
All research outputs
#1,484,617
of 25,374,917 outputs
Outputs from Genome Biology
#1,186
of 4,467 outputs
Outputs of similar age
#14,594
of 235,800 outputs
Outputs of similar age from Genome Biology
#22
of 58 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,800 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.