Title |
Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-49 |
Pubmed ID | |
Authors |
Peter JI Ellis, Tiffany J Morris, Benjamin M Skinner, Carole A Sargent, Mark H Vickers, Peter D Gluckman, Stewart Gilmour, Nabeel A Affara |
Abstract |
Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional environment. In a rat model, both male and female offspring of undernourished mothers are programmed to become obese, however postnatal leptin treatment gives discordant results between males and females. Leptin treatment is able to rescue the adverse programming effects in the female offspring of undernourished mothers, but not in their male offspring. Additionally, in these rats, postnatal leptin treatment of offspring from normally-nourished mothers programmes their male offspring to develop obesity in later life, while there is no comparable effect in their female offspring. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 86 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 16% |
Student > Bachelor | 13 | 15% |
Researcher | 10 | 11% |
Other | 6 | 7% |
Student > Doctoral Student | 6 | 7% |
Other | 22 | 25% |
Unknown | 16 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 24% |
Biochemistry, Genetics and Molecular Biology | 16 | 18% |
Medicine and Dentistry | 9 | 10% |
Nursing and Health Professions | 6 | 7% |
Immunology and Microbiology | 4 | 5% |
Other | 13 | 15% |
Unknown | 18 | 21% |