Title |
Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells
|
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Published in |
Stem Cell Research & Therapy, March 2014
|
DOI | 10.1186/scrt423 |
Pubmed ID | |
Authors |
Nancy Stanslowsky, Alexandra Haase, Ulrich Martin, Maximilian Naujock, Andreas Leffler, Reinhard Dengler, Florian Wegner |
Abstract |
Human induced pluripotent stem cells (hiPSCs) offer great promise for regenerative therapies or in vitro modelling of neurodegenerative disorders like Parkinson's disease. Currently, widely used cell sources for the generation of hiPSCs are somatic cells obtained from aged individuals. However, a critical issue concerning the potential clinical use of these iPSCs is mutations that accumulate over lifetime and are transferred onto iPSCs during reprogramming which may influence the functionality of cells differentiated from them. The aim of our study was to establish a differentiation strategy to efficiently generate neurons including dopaminergic cells from human cord blood-derived iPSCs (hCBiPSCs) as a juvenescent cell source and prove their functional maturation in vitro. |
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Geographical breakdown
Country | Count | As % |
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Canada | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 1% |
Australia | 1 | 1% |
Sweden | 1 | 1% |
Denmark | 1 | 1% |
United States | 1 | 1% |
Unknown | 81 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 19% |
Student > Master | 13 | 15% |
Student > Bachelor | 5 | 6% |
Student > Doctoral Student | 4 | 5% |
Other | 10 | 12% |
Unknown | 18 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Neuroscience | 9 | 10% |
Medicine and Dentistry | 8 | 9% |
Engineering | 2 | 2% |
Other | 7 | 8% |
Unknown | 19 | 22% |