Title |
Comparison of alterations in cerebral hemoglobin oxygenation in late life depression and Alzheimer’s disease as assessed by near-infrared spectroscopy
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Published in |
Behavioral and Brain Functions, March 2014
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DOI | 10.1186/1744-9081-10-8 |
Pubmed ID | |
Authors |
Hisashi Kito, Akiko Ryokawa, Yoshihiro Kinoshita, Daimei Sasayama, Nobuhiro Sugiyama, Tomomi Ogihara, Takehiko Yasaki, Tetsuya Hagiwara, Shin Inuzuka, Tohru Takahashi, Hirokazu Genno, Hiroshi Nose, Tokiji Hanihara, Shinsuke Washizuka, Naoji Amano |
Abstract |
Patients with Alzheimer's disease (AD) often present with apathy symptoms resembling the decreased motivation observed in depressed patients. Therefore, differentiating the initial phase of AD from late life depression may be difficult in some cases. Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that uses near-infrared light to measure changes in hemoglobin concentration on the cortical surface during activation tasks. The objective of this study was to investigate differences in brain activation associated with late life depression and with AD by means of NIRS. |
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