Title |
DNA damage response and DNA repair – dog as a model?
|
---|---|
Published in |
BMC Cancer, March 2014
|
DOI | 10.1186/1471-2407-14-203 |
Pubmed ID | |
Authors |
Nicole Grosse, Barbara van Loon, Carla Rohrer Bley |
Abstract |
Companion animals like dogs frequently develop tumors with age and similarly to human malignancies, display interpatient tumoral heterogeneity. Tumors are frequently characterized with regard to their mutation spectra, changes in gene expression or protein levels. Among others, these changes affect proteins involved in the DNA damage response (DDR), which served as a basis for the development of numerous clinically relevant cancer therapies. Even though the effects of different DNA damaging agents, as well as DDR kinetics, have been well characterized in mammalian cells in vitro, very little is so far known about the kinetics of DDR in tumor and normal tissues in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 17% |
Student > Master | 9 | 17% |
Student > Bachelor | 5 | 9% |
Student > Postgraduate | 5 | 9% |
Student > Doctoral Student | 4 | 8% |
Other | 14 | 26% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 14 | 26% |
Medicine and Dentistry | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Agricultural and Biological Sciences | 7 | 13% |
Psychology | 2 | 4% |
Other | 4 | 8% |
Unknown | 8 | 15% |