Title |
Differential expression of HIF-1α in CD44+CD24-/low breast ductal carcinomas
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Published in |
Diagnostic Pathology, August 2011
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DOI | 10.1186/1746-1596-6-73 |
Pubmed ID | |
Authors |
João Paulo Oliveira-Costa, Juliana S Zanetti, Giórgia G Silveira, Danilo F Soave, Lucinei R Oliveira, Verônica A Zorgetto, Fernando A Soares, Sérgio Zucoloto, Alfredo Ribeiro-Silva |
Abstract |
Cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bulk of tumor. Stem cells renewal and differentiation can be directly influenced by the oxygen levels of determined tissues, probably by the reduction of oxidative DNA damage in hypoxic regions, thus leading to a friendlier microenvironment, regarding to clonal expansion and for resistance to chemotherapeutic regimens. Furthermore, there have been strong data indicating a pivotal role of hypoxic niche in cancer stem cells development. There are evidence that hypoxia could drive the maintenance of CSC, via HIF-1α expression, but it still to be determined whether hypoxia markers are expressed in breast tumors presenting CD44+CD24-/low immunophenotype. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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China | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 17% |
Researcher | 7 | 17% |
Student > Bachelor | 5 | 12% |
Student > Postgraduate | 5 | 12% |
Student > Ph. D. Student | 4 | 10% |
Other | 8 | 20% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 39% |
Agricultural and Biological Sciences | 6 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Engineering | 2 | 5% |
Other | 3 | 7% |
Unknown | 8 | 20% |