Title |
Jaagsiekte sheep retrovirus detected in human lung cancer tissue arrays
|
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Published in |
BMC Research Notes, March 2014
|
DOI | 10.1186/1756-0500-7-160 |
Pubmed ID | |
Authors |
Nicolle M Linnerth-Petrik, Scott R Walsh, Paul N Bogner, Carl Morrison, Sarah K Wootton |
Abstract |
Adenocarcinoma is the most common type of non-small cell lung cancer and is frequently observed in non-smoking patients. Adenocarcinoma in-situ (formerly referred to as bronchioloalveolar carcinoma) is a subset of lung adenocarcinoma characterized by growth along alveolar septae without evidence of stromal, vascular, or pleural invasion, that disproportionately affects never-smokers, women, and Asians. Adenocarcinoma in-situ is morphologically and histologically similar to a contagious lung neoplasm of sheep called ovine pulmonary adenocarcinoma (OPA). OPA is caused by infection with the exogenous betaretrovirus, jaagsiekte sheep retrovirus (JSRV), whose envelope protein (Env) is a potent oncogene. Several studies have reported that a proportion of human lung adenocarcinomas are immunopositive for an antigen related to the Gag protein of JSRV, however other groups have been unable to verify these observations by PCR. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 5 | 19% |
Researcher | 5 | 19% |
Student > Master | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Lecturer | 2 | 8% |
Other | 3 | 12% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 35% |
Medicine and Dentistry | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Veterinary Science and Veterinary Medicine | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 19% |