Title |
Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array
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Published in |
BMC Genomics, March 2014
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DOI | 10.1186/1471-2164-15-210 |
Pubmed ID | |
Authors |
Anna-Maja Molin, Jonas Berglund, Matthew T Webster, Kerstin Lindblad-Toh |
Abstract |
Substantial contribution to phenotypic diversity is accounted for by copy number variants (CNV). In human, as well as other species, the effect of CNVs range from benign to directly disease-causing which motivates the continued investigations of CNVs. Previous canine genome-wide screenings for CNVs have been performed using high-resolution comparative genomic hybridisation arrays which have contributed with a detailed catalogue of CNVs. Here, we present the first CNV investigation in dogs based on the recently reported CanineHD 170 K genotyping array. The hitherto largest dataset in canine CNV discovery was assessed, 351 dogs from 30 different breeds, enabling identification of novel CNVs and a thorough characterisation of breed-specific CNVs. |
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Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
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Demographic breakdown
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Student > Ph. D. Student | 13 | 33% |
Researcher | 7 | 18% |
Student > Bachelor | 4 | 10% |
Student > Master | 4 | 10% |
Other | 2 | 5% |
Other | 6 | 15% |
Unknown | 3 | 8% |
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Biochemistry, Genetics and Molecular Biology | 8 | 21% |
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Medicine and Dentistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 4 | 10% |