Title |
Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin
|
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Published in |
BMC Cancer, March 2014
|
DOI | 10.1186/1471-2407-14-206 |
Pubmed ID | |
Authors |
Brian Hutzen, Hemant Kumar Bid, Peter J Houghton, Christopher R Pierson, Kimerly Powell, Anna Bratasz, Corey Raffel, Adam W Studebaker |
Abstract |
Medulloblastoma is the most common type of pediatric brain tumor. Although numerous factors influence patient survival rates, more than 30% of all cases will ultimately be refractory to conventional therapies. Current standards of care are also associated with significant morbidities, giving impetus for the development of new treatments. We have previously shown that oncolytic measles virotherapy is effective against medulloblastoma, leading to significant prolongation of survival and even cures in mouse xenograft models of localized and metastatic disease. Because medulloblastomas are known to be highly vascularized tumors, we reasoned that the addition of angiogenesis inhibitors could further enhance the efficacy of oncolytic measles virotherapy. Toward this end, we have engineered an oncolytic measles virus that express a fusion protein of endostatin and angiostatin, two endogenous and potent inhibitors of angiogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 21% |
Student > Master | 8 | 19% |
Researcher | 7 | 16% |
Student > Ph. D. Student | 5 | 12% |
Other | 3 | 7% |
Other | 4 | 9% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 30% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Immunology and Microbiology | 5 | 12% |
Agricultural and Biological Sciences | 4 | 9% |
Unspecified | 1 | 2% |
Other | 3 | 7% |
Unknown | 10 | 23% |