Title |
TopHat-Fusion: an algorithm for discovery of novel fusion transcripts
|
---|---|
Published in |
Genome Biology, August 2011
|
DOI | 10.1186/gb-2011-12-8-r72 |
Pubmed ID | |
Authors |
Daehwan Kim, Steven L Salzberg |
Abstract |
TopHat-Fusion is an algorithm designed to discover transcripts representing fusion gene products, which result from the breakage and re-joining of two different chromosomes, or from rearrangements within a chromosome. TopHat-Fusion is an enhanced version of TopHat, an efficient program that aligns RNA-seq reads without relying on existing annotation. Because it is independent of gene annotation, TopHat-Fusion can discover fusion products deriving from known genes, unknown genes and unannotated splice variants of known genes. Using RNA-seq data from breast and prostate cancer cell lines, we detected both previously reported and novel fusions with solid supporting evidence. TopHat-Fusion is available at http://tophat-fusion.sourceforge.net/. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 25% |
Germany | 2 | 17% |
France | 1 | 8% |
Brazil | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 9 | 75% |
Members of the public | 3 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 25 | 3% |
United Kingdom | 6 | <1% |
Germany | 5 | <1% |
France | 5 | <1% |
Korea, Republic of | 4 | <1% |
Norway | 3 | <1% |
Italy | 3 | <1% |
China | 3 | <1% |
Switzerland | 2 | <1% |
Other | 14 | 2% |
Unknown | 690 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 217 | 29% |
Student > Ph. D. Student | 169 | 22% |
Student > Master | 94 | 12% |
Student > Bachelor | 44 | 6% |
Student > Doctoral Student | 38 | 5% |
Other | 118 | 16% |
Unknown | 80 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 357 | 47% |
Biochemistry, Genetics and Molecular Biology | 149 | 20% |
Computer Science | 63 | 8% |
Medicine and Dentistry | 44 | 6% |
Neuroscience | 12 | 2% |
Other | 42 | 6% |
Unknown | 93 | 12% |