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Mathematically optimized cryoprotectant equilibration procedures for cryopreservation of human oocytes

Overview of attention for article published in Theoretical Biology and Medical Modelling, March 2014
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Title
Mathematically optimized cryoprotectant equilibration procedures for cryopreservation of human oocytes
Published in
Theoretical Biology and Medical Modelling, March 2014
DOI 10.1186/1742-4682-11-13
Pubmed ID
Authors

Allyson Fry Davidson, James D Benson, Adam Z Higgins

Abstract

Simple and effective cryopreservation of human oocytes would have an enormous impact on the financial and ethical constraints of human assisted reproduction. Recently, studies have demonstrated the potential for cryopreservation in an ice-free glassy state by equilibrating oocytes with high concentrations of cryoprotectants (CPAs) and rapidly cooling to liquid nitrogen temperatures. A major difficulty with this approach is that the high concentrations required for the avoidance of crystal formation (vitrification) also increase the risk of osmotic and toxic damage. We recently described a mathematical optimization approach for designing CPA equilibration procedures that avoid osmotic damage and minimize toxicity, and we presented optimized procedures for human oocytes involving continuous changes in solution composition.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Master 8 15%
Student > Ph. D. Student 7 13%
Student > Bachelor 6 11%
Student > Postgraduate 3 6%
Other 7 13%
Unknown 12 23%
Readers by discipline Count As %
Medicine and Dentistry 10 19%
Biochemistry, Genetics and Molecular Biology 8 15%
Agricultural and Biological Sciences 6 11%
Engineering 4 8%
Social Sciences 2 4%
Other 11 21%
Unknown 12 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2014.
All research outputs
#2,898,494
of 3,631,265 outputs
Outputs from Theoretical Biology and Medical Modelling
#103
of 144 outputs
Outputs of similar age
#74,217
of 93,712 outputs
Outputs of similar age from Theoretical Biology and Medical Modelling
#3
of 4 outputs
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So far Altmetric has tracked 144 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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