Title |
On the inflammatory response in metal-on-metal implants
|
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Published in |
Journal of Translational Medicine, March 2014
|
DOI | 10.1186/1479-5876-12-74 |
Pubmed ID | |
Authors |
Ulrike Dapunt, Thomas Giese, Felix Lasitschka, Jörn Reinders, Burkhard Lehner, Jan Philippe Kretzer, Volker Ewerbeck, Gertrud Maria Hänsch |
Abstract |
Metal-on-metal implants are a special form of hip endoprostheses that despite many advantages can entail serious complications due to release of wear particles from the implanted material. Metal wear particles presumably activate local host defence mechanisms, which causes a persistent inflammatory response with destruction of bone followed by a loosening of the implant. To better characterize this inflammatory response and to link inflammation to bone degradation, the local generation of proinflammatory and osteoclast-inducing cytokines was analysed, as was systemic T cell activation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 19% |
Student > Ph. D. Student | 6 | 19% |
Student > Bachelor | 4 | 13% |
Student > Master | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Other | 1 | 3% |
Unknown | 9 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Agricultural and Biological Sciences | 2 | 6% |
Materials Science | 2 | 6% |
Computer Science | 1 | 3% |
Other | 7 | 23% |
Unknown | 11 | 35% |