↓ Skip to main content

Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus

Overview of attention for article published in Arthritis Research & Therapy, January 2014
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
76 Dimensions

Readers on

mendeley
99 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus
Published in
Arthritis Research & Therapy, January 2014
DOI 10.1186/ar4518
Pubmed ID
Authors

Shunsei Hirohata, Yoshiyuki Arinuma, Tamiko Yanagida, Taku Yoshio

Abstract

Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications of the disease, its pathogenesis still remains unclear. Previous studies revealed that antibodies reactive with NMDA (N-methyl-D-aspartate) receptor NR2 (anti-NR2) are elevated in cerebrospinal fluid (CSF) of patients with diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), which is usually more recalcitrant than neurologic syndromes of NPSLE (focal NPSLE). Two mechanisms have been implicated for the elevation of CSF IgG, including intrathecal synthesis and transudation through the damaged blood-brain barrier (BBB). The present study was designed in order to elucidate the roles of BBB function and intrathecal synthesis of anti-NR2 in the elevation of CSF anti-NR2 with regard to the severity in NPSLE.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 1 1%
India 1 1%
Brazil 1 1%
Unknown 94 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 13%
Student > Master 13 13%
Student > Bachelor 13 13%
Student > Ph. D. Student 9 9%
Other 8 8%
Other 24 24%
Unknown 19 19%
Readers by discipline Count As %
Medicine and Dentistry 37 37%
Neuroscience 9 9%
Psychology 8 8%
Agricultural and Biological Sciences 5 5%
Immunology and Microbiology 3 3%
Other 8 8%
Unknown 29 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2021.
All research outputs
#6,305,632
of 21,365,584 outputs
Outputs from Arthritis Research & Therapy
#1,278
of 2,820 outputs
Outputs of similar age
#59,940
of 206,274 outputs
Outputs of similar age from Arthritis Research & Therapy
#2
of 3 outputs
Altmetric has tracked 21,365,584 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,820 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.