Title |
Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
|
---|---|
Published in |
Malaria Journal, July 2010
|
DOI | 10.1186/1475-2875-9-208 |
Pubmed ID | |
Authors |
Mario Dell'Agli, Germana V Galli, Michela Bulgari, Nicoletta Basilico, Sergio Romeo, Deepak Bhattacharya, Donatella Taramelli, Enrica Bosisio |
Abstract |
The sun-dried rind of the immature fruit of pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for the therapy and prophylaxis of malaria. The pathogenesis of cerebral malaria, a complication of the infection by Plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of TNF production. The in vitro anti-plasmodial activity of Punica granatum (Pg) was recently described. The aim of the present study was to explore whether the anti-malarial effect of OMARIA could also be sustained via other mechanisms among those associated to the host immune response. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Mauritius | 1 | <1% |
Spain | 1 | <1% |
Unknown | 98 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 16% |
Researcher | 16 | 16% |
Student > Master | 11 | 11% |
Student > Bachelor | 11 | 11% |
Student > Doctoral Student | 8 | 8% |
Other | 18 | 17% |
Unknown | 23 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 19% |
Medicine and Dentistry | 16 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 12% |
Biochemistry, Genetics and Molecular Biology | 9 | 9% |
Chemistry | 6 | 6% |
Other | 12 | 12% |
Unknown | 28 | 27% |