Title |
CCL3L1 copy number, CCR5genotype and susceptibility to tuberculosis
|
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Published in |
BMC Medical Genomics, January 2014
|
DOI | 10.1186/1471-2350-15-5 |
Pubmed ID | |
Authors |
Danielle Carpenter, Carmen Taype, Jon Goulding, Mike Levin, Brian Eley, Suzanne Anderson, Marie-Anne Shaw, John AL Armour |
Abstract |
Tuberculosis is a major infectious disease and functional studies have provided evidence that both the chemokine MIP-1α and its receptor CCR5 play a role in susceptibility to TB. Thus by measuring copy number variation of CCL3L1, one of the genes that encode MIP-1α, and genotyping a functional promoter polymorphism -2459A > G in CCR5 (rs1799987) we investigate the influence of MIP-1α and CCR5, independently and combined, in susceptibility to clinically active TB in three populations, a Peruvian population (n = 1132), a !Xhosa population (n = 605) and a South African Coloured population (n = 221). The three populations include patients with clinically diagnosed pulmonary TB, as well as other, less prevalent forms of extrapulmonary TB. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 23% |
Student > Master | 9 | 21% |
Student > Ph. D. Student | 7 | 16% |
Student > Bachelor | 4 | 9% |
Professor | 2 | 5% |
Other | 7 | 16% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 35% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Agricultural and Biological Sciences | 7 | 16% |
Environmental Science | 3 | 7% |
Engineering | 2 | 5% |
Other | 4 | 9% |
Unknown | 5 | 12% |