Title |
SYRCLE’s risk of bias tool for animal studies
|
---|---|
Published in |
BMC Medical Research Methodology, March 2014
|
DOI | 10.1186/1471-2288-14-43 |
Pubmed ID | |
Authors |
Carlijn R Hooijmans, Maroeska M Rovers, Rob BM de Vries, Marlies Leenaars, Merel Ritskes-Hoitinga, Miranda W Langendam |
Abstract |
Systematic Reviews (SRs) of experimental animal studies are not yet common practice, but awareness of the merits of conducting such SRs is steadily increasing. As animal intervention studies differ from randomized clinical trials (RCT) in many aspects, the methodology for SRs of clinical trials needs to be adapted and optimized for animal intervention studies. The Cochrane Collaboration developed a Risk of Bias (RoB) tool to establish consistency and avoid discrepancies in assessing the methodological quality of RCTs. A similar initiative is warranted in the field of animal experimentation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Romania | 3 | 17% |
United States | 1 | 6% |
Canada | 1 | 6% |
United Kingdom | 1 | 6% |
Belgium | 1 | 6% |
Germany | 1 | 6% |
Netherlands | 1 | 6% |
Singapore | 1 | 6% |
Unknown | 8 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 44% |
Scientists | 7 | 39% |
Practitioners (doctors, other healthcare professionals) | 3 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | <1% |
Netherlands | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Czechia | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Unknown | 1267 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 180 | 14% |
Student > Bachelor | 177 | 14% |
Student > Ph. D. Student | 138 | 11% |
Researcher | 114 | 9% |
Student > Doctoral Student | 86 | 7% |
Other | 165 | 13% |
Unknown | 414 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 323 | 25% |
Biochemistry, Genetics and Molecular Biology | 78 | 6% |
Agricultural and Biological Sciences | 74 | 6% |
Neuroscience | 67 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 64 | 5% |
Other | 186 | 15% |
Unknown | 482 | 38% |