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Human serum inhibits adhesion and biofilm formation in Candida albicans

Overview of attention for article published in BMC Microbiology, March 2014
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Title
Human serum inhibits adhesion and biofilm formation in Candida albicans
Published in
BMC Microbiology, March 2014
DOI 10.1186/1471-2180-14-80
Pubmed ID
Authors

Xiurong Ding, Zhizhong Liu, Jianrong Su, Donghui Yan

Abstract

Candida albicans can form biofilms on intravenous catheters; this process plays a key role in the pathogenesis of catheter infections. This study evaluated the effect of human serum (HS) on C. albicans biofilm formation and the expression of adhesion-related genes in vitro. A C. albicans laboratory strain (ATCC90028) and three clinical strains were grown for 24 h in RPMI 1640 supplemented with HS or RPMI 1640 alone (as a control). The growth of biofilm cells of four strains was monitored by a Live Cell Movie Analyzer, and by XTT reduction assay. The expression of the adhesion-related genes BCR1, ALS1, ALS3, HWP1 and ECE1 was analyzed by RT-PCR at three time points (60 min, 90 min, and 24 h).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 2 2%
Russia 1 1%
India 1 1%
Unknown 85 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 27%
Student > Master 13 15%
Researcher 12 13%
Student > Bachelor 11 12%
Student > Doctoral Student 4 4%
Other 10 11%
Unknown 15 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 27%
Biochemistry, Genetics and Molecular Biology 11 12%
Immunology and Microbiology 9 10%
Medicine and Dentistry 8 9%
Veterinary Science and Veterinary Medicine 3 3%
Other 12 13%
Unknown 22 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2014.
All research outputs
#17,718,054
of 22,751,628 outputs
Outputs from BMC Microbiology
#1,995
of 3,180 outputs
Outputs of similar age
#155,285
of 224,799 outputs
Outputs of similar age from BMC Microbiology
#32
of 47 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,180 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,799 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.