Title |
Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression
|
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Published in |
BMC Molecular and Cell Biology, April 2011
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DOI | 10.1186/1471-2199-12-13 |
Pubmed ID | |
Authors |
Justin A Gosnell, Tim W Christensen |
Abstract |
Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient passage though S phase. The Ctf4 protein has been shown to be a central member of the replication fork and links the replicative MCM helicase and DNA polymerase α primase. In addition, it has been implicated as a member of a complex that promotes replication fork stability, the Fork Protection Complex (FPC), and as being important for sister chromatid cohesion. As such, understanding the role of Ctf4 within the context of a multicellular organism will be integral to our understanding of its potential role in developmental and disease processes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 37% |
Student > Ph. D. Student | 7 | 18% |
Student > Master | 4 | 11% |
Professor | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 3 | 8% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 37% |
Agricultural and Biological Sciences | 14 | 37% |
Nursing and Health Professions | 1 | 3% |
Economics, Econometrics and Finance | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 4 | 11% |