Title |
Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study
|
---|---|
Published in |
BMC Ophthalmology, July 2017
|
DOI | 10.1186/s12886-017-0515-2 |
Pubmed ID | |
Authors |
Young-Sool Hah, Hye Jin Chung, Sneha B. Sontakke, In-Young Chung, Sunmi Ju, Seong-Wook Seo, Ji-Myong Yoo, Seong-Jae Kim |
Abstract |
To measure ascorbic acid concentration in aqueous humor of patients with cataract after oral or intravenous vitamin C supplementation. Forty-two eyes of 42 patients with senile cataract who underwent uncomplicated cataract surgery were enrolled. Patients (n = 14 each) were administered oral vitamin C (2 g), intravenous vitamin C (20 g) or no treatment (control group) on the day before surgery. Samples of aqueous humor (0.1 cm(3)) were obtained by anterior chamber aspiration at the beginning of surgery and stored at -80 °C. Ascorbic acid concentration in aqueous humor was measured by high-pressure liquid chromatography. The mean age at surgery was 62.5 years, with no difference among the three groups. The mean ± standard deviation concentrations of ascorbic acid in aqueous humor in the control and oral and intravenous vitamin C groups were 1347 ± 331 μmol/L, 1859 ± 408 μmol/L and 2387 ± 445 μmol/L, respectively. Ascorbic acid concentration was significantly lower in the control than in the oral (P < 0.01) and intravenous (P < 0.001) vitamin C groups and was significantly higher in the intravenous than in the oral vitamin C group (P < 0.05). Ascorbic acid concentration in aqueous humor is increased by systemic vitamin C supplementation, with intravenous administration being more effective than oral administration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 17% |
Student > Bachelor | 5 | 12% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Professor | 3 | 7% |
Other | 5 | 12% |
Unknown | 14 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Nursing and Health Professions | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 4 | 10% |
Unknown | 19 | 46% |