You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
|
|---|---|
| Published in |
Journal of Hematology & Oncology, February 2017
|
| DOI | 10.1186/s13045-017-0410-6 |
| Pubmed ID | |
| Authors |
Chau-To Kwok, Amy D. Marshall, John E. J. Rasko, Justin J. L. Wong |
| Abstract |
Methylation of N(6) adenosine (m(6)A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the development of human cancers is poorly understood. By analyzing datasets from the Cancer Genome Atlas Research Network (TCGA) acute myeloid leukemia (AML) study, we discover that mutations and/or copy number variations of m(6)A regulatory genes are strongly associated with the presence of TP53 mutations in AML patients. Further, our analyses reveal that alterations in m(6)A regulatory genes confer a worse survival in AML. Our work indicates that genetic alterations of m(6)A regulatory genes may cooperate with TP53 and/or its regulator/downstream targets in the pathogenesis and/or maintenance of AML. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 87 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 26% |
| Researcher | 16 | 18% |
| Student > Bachelor | 11 | 13% |
| Student > Master | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 7 | 8% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 42% |
| Medicine and Dentistry | 13 | 15% |
| Agricultural and Biological Sciences | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 23 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2017.
All research outputs
#15,470,944
of 22,990,068 outputs
Outputs from Journal of Hematology & Oncology
#786
of 1,198 outputs
Outputs of similar age
#256,968
of 420,441 outputs
Outputs of similar age from Journal of Hematology & Oncology
#27
of 42 outputs
Altmetric has tracked 22,990,068 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,441 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.