Title |
Identification of a novel biomarker candidate, a 4.8-kDa peptide fragment from a neurosecretory protein VGF precursor, by proteomic analysis of cerebrospinal fluid from children with acute encephalopathy using SELDI-TOF-MS
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Published in |
BMC Neurology, August 2011
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DOI | 10.1186/1471-2377-11-101 |
Pubmed ID | |
Authors |
Takeshi Asano, Shinya Koizumi, Atsushi Takagi, Takayuki Hatori, Kentaroh Kuwabara, Osamu Fujino, Yoshitaka Fukunaga |
Abstract |
Acute encephalopathy includes rapid deterioration and has a poor prognosis. Early intervention is essential to prevent progression of the disease and subsequent neurologic complications. However, in the acute period, true encephalopathy cannot easily be differentiated from febrile seizures, especially febrile seizures of the complex type. Thus, an early diagnostic marker has been sought in order to enable early intervention. The purpose of this study was to identify a novel marker candidate protein differentially expressed in the cerebrospinal fluid (CSF) of children with encephalopathy using proteomic analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 2% |
Poland | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 25% |
Researcher | 8 | 14% |
Student > Bachelor | 6 | 10% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 13 | 22% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 25% |
Agricultural and Biological Sciences | 12 | 20% |
Nursing and Health Professions | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Psychology | 4 | 7% |
Other | 11 | 19% |
Unknown | 9 | 15% |