Title |
Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology
|
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Published in |
Critical Care, June 2003
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DOI | 10.1186/cc2338 |
Pubmed ID | |
Authors |
Cheryl L Holmes, Donald W Landry, John T Granton |
Abstract |
Vasopressin is emerging as a rational therapy for vasodilatory shock states. In part 1 of the review we discussed the structure and function of the various vasopressin receptors. In part 2 we discuss vascular smooth muscle contraction pathways with an emphasis on the effects of vasopressin on ATP-sensitive K+ channels, nitric oxide pathways, and interaction with adrenergic agents. We explore the complex and contradictory studies of vasopressin on cardiac inotropy and coronary vascular tone. Finally, we summarize the clinical studies of vasopressin in shock states, which to date have been relatively small and have focused on physiologic outcomes. Because of potential adverse effects of vasopressin, clinical use of vasopressin in vasodilatory shock should await a randomized controlled trial of the effect of vasopressin's effect on outcomes such as organ failure and mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
United Kingdom | 2 | 1% |
Sweden | 1 | <1% |
Japan | 1 | <1% |
Peru | 1 | <1% |
Unknown | 134 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 22 | 15% |
Student > Ph. D. Student | 15 | 11% |
Researcher | 13 | 9% |
Student > Master | 13 | 9% |
Student > Bachelor | 10 | 7% |
Other | 40 | 28% |
Unknown | 29 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 77 | 54% |
Agricultural and Biological Sciences | 11 | 8% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Veterinary Science and Veterinary Medicine | 4 | 3% |
Psychology | 3 | 2% |
Other | 11 | 8% |
Unknown | 30 | 21% |