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Synergistic effects of noradrenergic modulation with atomoxetine and 10 Hz repetitive transcranial magnetic stimulation on motor learning in healthy humans

Overview of attention for article published in BMC Neuroscience, April 2014
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Title
Synergistic effects of noradrenergic modulation with atomoxetine and 10 Hz repetitive transcranial magnetic stimulation on motor learning in healthy humans
Published in
BMC Neuroscience, April 2014
DOI 10.1186/1471-2202-15-46
Pubmed ID
Authors

Matthias Sczesny-Kaiser, Alica Bauknecht, Oliver Höffken, Martin Tegenthoff, Hubert R Dinse, Dirk Jancke, Klaus Funke, Peter Schwenkreis

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is able to induce changes in neuronal activity that outlast stimulation. The underlying mechanisms are not completely understood. They might be analogous to long-term potentiation or depression, as the duration of the effects seems to implicate changes in synaptic plasticity. Norepinephrine (NE) has been shown to play a crucial role in neuronal plasticity in the healthy and injured human brain. Atomoxetine (ATX) and other NE reuptake inhibitors have been shown to increase excitability in different systems and to influence learning processes. Thus, the combination of two facilitative interventions may lead to further increase in excitability and motor learning. But in some cases homeostatic metaplasticity might protect the brain from harmful hyperexcitability. In this study, the combination of 60 mg ATX and 10 Hz rTMS over the primary motor cortex was used to examine changes in cortical excitability and motor learning and to investigate their influence on synaptic plasticity mechanisms.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Serbia 1 1%
Canada 1 1%
Switzerland 1 1%
Unknown 79 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 19%
Student > Master 12 14%
Student > Bachelor 10 12%
Student > Ph. D. Student 7 8%
Professor 7 8%
Other 19 23%
Unknown 12 14%
Readers by discipline Count As %
Medicine and Dentistry 21 25%
Neuroscience 20 24%
Psychology 10 12%
Agricultural and Biological Sciences 8 10%
Nursing and Health Professions 1 1%
Other 4 5%
Unknown 19 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2014.
All research outputs
#13,406,705
of 22,751,628 outputs
Outputs from BMC Neuroscience
#547
of 1,242 outputs
Outputs of similar age
#110,556
of 225,531 outputs
Outputs of similar age from BMC Neuroscience
#11
of 29 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,242 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,531 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.