Title |
Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
|
---|---|
Published in |
Critical Care, April 2014
|
DOI | 10.1186/cc13813 |
Pubmed ID | |
Authors |
Joerg Krebs, Charalambos Tsagogiorgas, Paolo Pelosi, Patricia RM Rocco, Maximilia Hottenrott, Carsten Sticht, Benito Yard, Thomas Luecke |
Abstract |
The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 milliliters per kilogram ideal body weight) tidal volume (V(T)) ventilation with open lung positive end-expiratory pressure (LV(T)/OLPEEP) set according to the minimal static elastance of the respiratory system, attenuates the impact of massive brain damage on gas-exchange, respiratory mechanics, lung histology and whole genome alterations compared with high (12 milliliters per kilogram ideal body weight) V(T) and low positive end-expiratory pressure ventilation (HV(T)/LPEEP). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 7% |
Unknown | 41 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 18% |
Student > Postgraduate | 5 | 11% |
Professor > Associate Professor | 5 | 11% |
Researcher | 4 | 9% |
Professor | 4 | 9% |
Other | 6 | 14% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Agricultural and Biological Sciences | 2 | 5% |
Psychology | 1 | 2% |
Other | 2 | 5% |
Unknown | 13 | 30% |