Title |
NOXclass: prediction of protein-protein interaction types
|
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Published in |
BMC Bioinformatics, January 2006
|
DOI | 10.1186/1471-2105-7-27 |
Pubmed ID | |
Authors |
Hongbo Zhu, Francisco S Domingues, Ingolf Sommer, Thomas Lengauer |
Abstract |
Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level. Interpretation of these models requires the distinction between non-specific crystal packing contacts and biologically relevant interactions. This has been investigated previously and classification approaches have been proposed. However, less attention has been devoted to distinguishing different types of biological interactions. These interactions are classified as obligate and non-obligate according to the effect of the complex formation on the stability of the protomers. So far no automatic classification methods for distinguishing obligate, non-obligate and crystal packing interactions have been made available. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 81 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 7% |
Student > Ph. D. Student | 3 | 4% |
Student > Doctoral Student | 2 | 2% |
Student > Bachelor | 1 | 1% |
Professor | 1 | 1% |
Other | 4 | 5% |
Unknown | 66 | 80% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Medicine and Dentistry | 1 | 1% |
Other | 2 | 2% |
Unknown | 66 | 80% |