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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
|
|---|---|
| Published in |
Molecular Cancer, February 2017
|
| DOI | 10.1186/s12943-017-0595-x |
| Pubmed ID | |
| Authors |
Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren, Ralf Hass |
| Abstract |
The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In order to be able to eradicate these CSCs with novel classes of anti-cancer therapeutics, a better understanding of their biology and clinically-relevant traits is mandatory. Several requirements and functions of a CSC niche physiology are combined with current concepts for CSC generation such as development in a hierarchical tumor model, by stochastic processes, or via a retrodifferentiation program. Moreover, progressive adaptation of endothelial cells and recruited immune and stromal cells to the tumor site substantially contribute to generate a tumor growth-permissive environment resembling a CSC niche. Particular emphasis is put on the pivotal role of multipotent mesenchymal stroma/stem cells (MSCs) in supporting CSC development by various kinds of interaction and cell fusion to form hybrid tumor cells. A better knowledge of CSC niche physiology may increase the chances that cancer stemness-depleting interventions ultimately result in arrest of tumor growth and metastasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 19% |
| Student > Bachelor | 23 | 16% |
| Researcher | 19 | 13% |
| Student > Master | 18 | 12% |
| Professor > Associate Professor | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 50 | 34% |
| Medicine and Dentistry | 22 | 15% |
| Agricultural and Biological Sciences | 16 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Immunology and Microbiology | 6 | 4% |
| Other | 15 | 10% |
| Unknown | 30 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2022.
All research outputs
#2,703,826
of 23,151,189 outputs
Outputs from Molecular Cancer
#147
of 1,743 outputs
Outputs of similar age
#57,992
of 421,157 outputs
Outputs of similar age from Molecular Cancer
#2
of 43 outputs
Altmetric has tracked 23,151,189 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,743 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,157 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.