Title |
transAlign: using amino acids to facilitate the multiple alignment of protein-coding DNA sequences
|
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Published in |
BMC Bioinformatics, June 2005
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DOI | 10.1186/1471-2105-6-156 |
Pubmed ID | |
Authors |
Olaf RP Bininda-Emonds |
Abstract |
Alignments of homologous DNA sequences are crucial for comparative genomics and phylogenetic analysis. However, multiple alignment represents a computationally difficult problem. For protein-coding DNA sequences, it is more advantageous in terms of both speed and accuracy to align the amino-acid sequences specified by the DNA sequences rather than the DNA sequences themselves. Many implementations making use of this concept of "translated alignments" are incomplete in the sense that they require the user to manually translate the DNA sequences and to perform the amino-acid alignment. As such, they are not well suited to large-scale automated alignments of large and/or numerous DNA data sets. |
Mendeley readers
Geographical breakdown
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Germany | 2 | 1% |
United Kingdom | 2 | 1% |
Chile | 1 | <1% |
France | 1 | <1% |
Japan | 1 | <1% |
Canada | 1 | <1% |
Unknown | 146 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 41 | 26% |
Student > Ph. D. Student | 28 | 18% |
Student > Master | 19 | 12% |
Professor > Associate Professor | 11 | 7% |
Student > Doctoral Student | 10 | 6% |
Other | 30 | 19% |
Unknown | 20 | 13% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 24 | 15% |
Computer Science | 5 | 3% |
Earth and Planetary Sciences | 3 | 2% |
Immunology and Microbiology | 2 | 1% |
Other | 10 | 6% |
Unknown | 25 | 16% |