Title |
Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors
|
---|---|
Published in |
Molecular Brain, April 2014
|
DOI | 10.1186/1756-6606-7-24 |
Pubmed ID | |
Authors |
Zhi Zhou, Kazuhisa Kohda, Keiji Ibata, Jun Kohyama, Wado Akamatsu, Michisuke Yuzaki, Hirotaka James Okano, Erika Sasaki, Hideyuki Okano |
Abstract |
The common marmoset (Callithrix jacchus) is a New World primate sharing many similarities with humans. Recently developed technology for generating transgenic marmosets has opened new avenues for faithful recapitulation of human diseases, which could not be achieved in rodent models. However, the longer lifespan of common marmosets compared with rodents may result in an extended period for in vivo analysis of common marmoset disease models. Therefore, establishing rapid and efficient techniques for obtaining neuronal cells from transgenic individuals that enable in vitro analysis of molecular mechanisms underlying diseases are required. Recently, several groups have reported on methods, termed direct reprogramming, to generate neuronal cells by defined factors from somatic cells of various kinds of species, including mouse and human. The aim of the present study was to determine whether direct reprogramming technology was applicable to common marmosets. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 24% |
Student > Ph. D. Student | 12 | 21% |
Student > Master | 8 | 14% |
Student > Postgraduate | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 10 | 17% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Agricultural and Biological Sciences | 12 | 21% |
Medicine and Dentistry | 11 | 19% |
Neuroscience | 9 | 16% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 9% |
Unknown | 7 | 12% |