Title |
Prospective study of high-risk, BRCA1/2-mutation negative women: the ‘negative study’
|
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Published in |
BMC Cancer, March 2014
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DOI | 10.1186/1471-2407-14-221 |
Pubmed ID | |
Authors |
Joanne Kotsopoulos, Kelly Metcalfe, Jill Alston, Dina Nikitina, Ophira Ginsburg, Andrea Eisen, Rochelle Demsky, Mohammad Akbari, Kevin Zbuk, Steven A Narod |
Abstract |
We previously reported that women from high-risk families who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation were four times more likely to develop breast cancer compared to women in the general population. Preventive measures and risk factors for breast cancer development in these high-risk women have not been evaluated to the same extent as BRCA1/2 positive women. Further, there is virtually no scientific evidence about best practices in their management and care. The proposed study will examine a role of genetic and non-genetic factors and develop the systems and parameters for the monitoring and surveillance necessary to help establish guidelines for the care of this high-risk population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 3% |
Canada | 1 | 3% |
Unknown | 35 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 19% |
Researcher | 6 | 16% |
Professor > Associate Professor | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 5 | 14% |
Unknown | 11 | 30% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 10 | 27% |
Medicine and Dentistry | 9 | 24% |
Agricultural and Biological Sciences | 4 | 11% |
Social Sciences | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 32% |