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Multi-TGDR, a multi-class regularization method, identifies the metabolic profiles of hepatocellular carcinoma and cirrhosis infected with hepatitis B or hepatitis C virus

Overview of attention for article published in BMC Bioinformatics, April 2014
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Title
Multi-TGDR, a multi-class regularization method, identifies the metabolic profiles of hepatocellular carcinoma and cirrhosis infected with hepatitis B or hepatitis C virus
Published in
BMC Bioinformatics, April 2014
DOI 10.1186/1471-2105-15-97
Pubmed ID
Authors

Suyan Tian, Howard H Chang, Chi Wang, Jing Jiang, Xiaomei Wang, Junqi Niu

Abstract

Over the last decade, metabolomics has evolved into a mainstream enterprise utilized by many laboratories globally. Like other "omics" data, metabolomics data has the characteristics of a smaller sample size compared to the number of features evaluated. Thus the selection of an optimal subset of features with a supervised classifier is imperative. We extended an existing feature selection algorithm, threshold gradient descent regularization (TGDR), to handle multi-class classification of "omics" data, and proposed two such extensions referred to as multi-TGDR. Both multi-TGDR frameworks were used to analyze a metabolomics dataset that compares the metabolic profiles of hepatocellular carcinoma (HCC) infected with hepatitis B (HBV) or C virus (HCV) with that of cirrhosis induced by HBV/HCV infection; the goal was to improve early-stage diagnosis of HCC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 8%
Russia 1 4%
Unknown 21 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 38%
Student > Master 3 13%
Student > Doctoral Student 2 8%
Other 2 8%
Student > Postgraduate 2 8%
Other 5 21%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Agricultural and Biological Sciences 6 25%
Biochemistry, Genetics and Molecular Biology 2 8%
Mathematics 1 4%
Computer Science 1 4%
Other 3 13%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2014.
All research outputs
#18,369,403
of 22,751,628 outputs
Outputs from BMC Bioinformatics
#6,301
of 7,269 outputs
Outputs of similar age
#163,661
of 226,135 outputs
Outputs of similar age from BMC Bioinformatics
#93
of 114 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,269 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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