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Mendeley readers
| Title |
Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, March 2014
|
| DOI | 10.1186/ar4509 |
| Pubmed ID | |
| Authors |
Yoony YJ Gent, Karin Weijers, Carla FM Molthoff, Albert D Windhorst, Marc C Huisman, Michael Kassiou, Gerrit Jansen, Adriaan A Lammertsma, Conny J van der Laken |
| Abstract |
Early diagnosis of and subsequent monitoring of therapy for rheumatoid arthritis (RA) could benefit from detection of (sub)clinical synovitis. Imaging of (sub)clinical arthritis by targeting the translocator protein (TSPO) on activated macrophages is feasible using (R)-[11C] PK11195-based positron emission tomography (PET), but clinical applications are limited by background uptake in peri-articular bone/bone marrow. The purpose of the present study was to evaluate two other TSPO ligands with potentially lower background uptake in neurological studies, [11C]DPA-713 and [18F]DPA-714, in a rat model of arthritis. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Japan | 1 | 3% |
| Unknown | 38 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 18% |
| Student > Master | 7 | 18% |
| Student > Ph. D. Student | 6 | 15% |
| Other | 6 | 15% |
| Professor | 4 | 10% |
| Other | 7 | 18% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 50% |
| Agricultural and Biological Sciences | 4 | 10% |
| Chemistry | 3 | 8% |
| Engineering | 2 | 5% |
| Physics and Astronomy | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 7 | 18% |