Title |
Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K
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Published in |
BMC Bioinformatics, October 2013
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DOI | 10.1186/1471-2105-14-s16-s7 |
Pubmed ID | |
Authors |
Chinh Tran-To Su, Xuchang Ouyang, Jie Zheng, Chee-Keong Kwoh |
Abstract |
Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in China. To-date, there have been more than 100 infections with 23 deaths. It is more worrying as this viral strain has never been detected in humans and only been found to be of low-pathogenicity. Currently, there are 3 effective neuraminidase inhibitors for this H7N9 virus strain, i.e. oseltamivir, zanamivir, and peramivir. These drugs have been used for treatment of the H7N9 influenza in China. However, how these inhibitors work and affect the binding cavity of the novel H7N9 neuraminidase in the presence of potential mutations has not been disclosed. In our study, we investigate steric effects and subsequently show the conformational restraints of the inhibitor-binding site of the non-mutated and mutated H7N9 neuraminidase structures to different drug compounds. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 3% |
Germany | 1 | 3% |
Unknown | 28 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 27% |
Student > Bachelor | 5 | 17% |
Student > Master | 4 | 13% |
Researcher | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Other | 4 | 13% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 40% |
Medicine and Dentistry | 6 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Immunology and Microbiology | 2 | 7% |
Environmental Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 4 | 13% |