Title |
Invasive group A Streptococcus disease in French-Canadian children is not associated with a defect in MyD88/IRAK4-pathway
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Published in |
Allergy, Asthma & Clinical Immunology, February 2014
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DOI | 10.1186/1710-1492-10-9 |
Pubmed ID | |
Authors |
Isabel Fernandez, Rose-Marie Brito, Philippe Bidet, Fabien Rallu, Celine Laferrière, Philippe Ovetchkine, Francoise Le Deist |
Abstract |
Beta-hemolytic Group A Streptococcus invasive disease (iGASd) has been subject to intense research since its re-emergence in the late 1980s. In Quebec, an increase in the number of severe iGASd cases has recently been observed. Because of the inter-individual variability in the severity of iGASd, a hereditary predisposition to invasive disease can be suspected. Given that iGASd occurs in MyD88- and IRAK4-deficient patients, although rarely, the increasing frequency of iGASd in the population of French-Canadian children may be associated with a deficiency in the host's innate immune response. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 1 | 7% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Unknown | 12 | 80% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 13% |
Medicine and Dentistry | 1 | 7% |
Unknown | 12 | 80% |