Title |
Predicting HLA genotypes using unphased and flanking single-nucleotide polymorphisms in Han Chinese population
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-81 |
Pubmed ID | |
Authors |
Ai-Ru Hsieh, Su-Wei Chang, Pei-Lung Chen, Chen-Chung Chu, Ching-Lin Hsiao, Wei-Shiung Yang, Chien-Ching Chang, Jer-Yuarn Wu, Yuan-Tsong Chen, Tien-Chun Chang, Cathy SJ Fann |
Abstract |
Genetic variation associated with human leukocyte antigen (HLA) genes has immunological functions and is associated with autoimmune diseases. To date, large-scale studies involving classical HLA genes have been limited by time-consuming and expensive HLA-typing technologies. To reduce these costs, single-nucleotide polymorphisms (SNPs) have been used to predict HLA-allele types. Although HLA allelic distributions differ among populations, most prediction model of HLA genes are based on Caucasian samples, with few reported studies involving non-Caucasians. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Malaysia | 1 | 3% |
Netherlands | 1 | 3% |
Australia | 1 | 3% |
Unknown | 31 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 21% |
Student > Ph. D. Student | 6 | 18% |
Other | 5 | 15% |
Student > Bachelor | 3 | 9% |
Student > Master | 3 | 9% |
Other | 4 | 12% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 26% |
Agricultural and Biological Sciences | 9 | 26% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Computer Science | 3 | 9% |
Unspecified | 1 | 3% |
Other | 2 | 6% |
Unknown | 6 | 18% |