Title |
Sex-dependent genetic effects on immune responses to a parasitic nematode
|
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Published in |
BMC Genomics, March 2014
|
DOI | 10.1186/1471-2164-15-193 |
Pubmed ID | |
Authors |
Kelly S Hayes, Reinmar Hager, Richard K Grencis |
Abstract |
Many disease aetiologies have sex specific effects, which have important implications for disease management. It is now becoming increasingly evident that such effects are the result of the differential expression of autosomal genes rather than sex-specific genes. Such sex-specific variation in the response to Trichuris muris, a murine parasitic nematode infection and model for the human parasitic nematode T. trichiura, has been well documented, however, the underlying genetic causes of these differences have been largely neglected. We used the BXD mouse set of recombinant inbred strains to identify sex-specific loci that contribute to immune phenotypes in T. muris infection. |
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