Title |
Gene expression profiling of intestinal regeneration in the sea cucumber
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Published in |
BMC Genomics, June 2009
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DOI | 10.1186/1471-2164-10-262 |
Pubmed ID | |
Authors |
Pablo A Ortiz-Pineda, Francisco Ramírez-Gómez, Judit Pérez-Ortiz, Sebastián González-Díaz, Francisco Santiago-De Jesús, Josue Hernández-Pasos, Cristina Del Valle-Avila, Carmencita Rojas-Cartagena, Edna C Suárez-Castillo, Karen Tossas, Ana T Méndez-Merced, José L Roig-López, Humberto Ortiz-Zuazaga, José E García-Arrarás |
Abstract |
Among deuterostomes, the regenerative potential is maximally expressed in echinoderms, animals that can quickly replace most injured organs. In particular, sea cucumbers are excellent models for studying organ regeneration since they regenerate their digestive tract after evisceration. However, echinoderms have been sidelined in modern regeneration studies partially because of the lack of genome-wide profiling approaches afforded by modern genomic tools.For the last decade, our laboratory has been using the sea cucumber Holothuria glaberrima to dissect the cellular and molecular events that allow for such amazing regenerative processes. We have already established an EST database obtained from cDNA libraries of normal and regenerating intestine at two different regeneration stages. This database now has over 7000 sequences. |
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Mendeley readers
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