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Mendeley readers
| Title |
MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
|
|---|---|
| Published in |
Molecular Cancer, June 2010
|
| DOI | 10.1186/1476-4598-9-169 |
| Pubmed ID | |
| Authors |
Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata, Masao Tanaka |
| Abstract |
Recently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial to mesenchymal transition (EMT). Especially, the expression of miR-200c has been shown to be associated with upregulating the expression of E-cadherin, a gene known to be involved in pancreatic cancer behavior. However, the significance of miR-200c in pancreatic cancer is unknown. In the present study, we investigated the relationship between E-cadherin and miR-200c expression in a panel of 14 pancreatic cancer cell lines and in macro-dissected formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from 99 patients who underwent pancreatectomy for pancreatic cancer. We also investigated the effects of miR-200c on the proliferation and invasion of pancreatic cancer cells. We found that patients with high levels of miR-200c expression had significantly better survival rates than those with low levels of miR-200c expression. We also found a remarkably strong correlation between the levels of miR-200c and E-cadherin expression. These data indicate that miR-200c may play a role in the pancreatic cancer biology and may be a novel marker for the prognosis of pancreatic cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Australia | 1 | 1% |
| Argentina | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 80 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 31% |
| Researcher | 17 | 20% |
| Student > Master | 7 | 8% |
| Professor > Associate Professor | 6 | 7% |
| Student > Doctoral Student | 4 | 5% |
| Other | 7 | 8% |
| Unknown | 18 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 26% |
| Biochemistry, Genetics and Molecular Biology | 19 | 22% |
| Medicine and Dentistry | 14 | 16% |
| Engineering | 3 | 4% |
| Chemistry | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 20 | 24% |