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Mendeley readers
| Title |
A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition
|
|---|---|
| Published in |
Biomarker Research, February 2017
|
| DOI | 10.1186/s40364-017-0086-7 |
| Pubmed ID | |
| Authors |
M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis, L. H. Wexler |
| Abstract |
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 18% |
| Student > Bachelor | 3 | 18% |
| Student > Master | 3 | 18% |
| Professor | 2 | 12% |
| Student > Doctoral Student | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 47% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Arts and Humanities | 1 | 6% |
| Nursing and Health Professions | 1 | 6% |
| Neuroscience | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 29% |